The nucleus of mammalian cells is highly compartmentalized both in terms of DNA and protein organization. Speckles are large membrane-less irregularly shaped nuclear condensates with a dynamic composition of hundreds of different proteins, many of which are involved in RNA splicing. Evidence from recent studies points towards an interesting connection between the evolution of nuclear speckles and genome structure in terms of base composition, gene clustering and 3D-genome organization...Read more

In this edition of multiplex tissue image of the month, meiosis-associated BEN domain containing 2 (gene: BEND2) is showcased within developing spermatocytes in testis...Read more

The protein expression of SHC adaptor protein 2 (gene: SHC2) within alpha cells of endocrine pancreas is explored with multiplex immunohistochemistry (mIHC/IF) in the latest update of Human Protein Atlas...Read more

Do you remember the outbreak of avian flu back in 2005? This outbreak was associated with a substantial number of human infections by the avian influenza A (IAV) virus H5N1. Almost all human cases were linked to close contact with infected, dying, or dead poultry, rather than human-to-human transmission, but the virus was highly lethal. This sparked awareness of the pandemic threat posed by zoonotic transmission of viruses, also among the general public...Read more

Using multiplex immunohistochemistry (mIHC/IF), the spatial expression pattern of transmembrane protein 213 (gene: TMEM213) is displayed in ductal structures of the salivary gland...Read more