In a review article published in Pharmacological reviews the current knowledge of molecular features, functions, and opportunities for therapeutic targeting of human and mammalian aGPCRs is summarised.

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. Ever since aGPCRs were recognized as a receptor family and alternatively classified as B2 GPCRs, researchers across many scientific research fields have focused on elucidating their molecular architecture, biochemical features, pharmacological properties, physiological functions, and involvement in disease.

In this review an updated overview of human and mammalian aGPCRs, structure, function and distribution in tissues and cells is presented.

Read the article

Take a look at ADGRA3 or the other aGPCRS in the Human Protein Atlas.